This page covers the ingredients found in CholesLo™ and discusses WHY they work, including links to clinical and scientific studies.. Under the below "Supplement Facts", you will see a list of all the specific ingredients and a short overview about their benefits, pros and cons.
|Ingredients||Amount Per Serving||%DV/RTI*|
|Synergy Optimizer™ Blend||746.50 MGS||†|
|Lipid Optimizing System [Cholesterol, HDL/LDL & Triglycerides]:|
Red Yeast Rice (5.0% Extract, Citrinin removed))
Artichoke Leaf Extract 2.5% (STD: 15% Chlorogenic Acid, 5% Cynarin)
Phytosterols Complex (40% extract from non-GMO pine tree extract)
Garlic (Extract 5% alliin)
Guggulsterones (10% Pure Extract; E and Z)
Policosanol (from Sugar Cane - Saccharum species)
|Liver Cleansing Formula:|
Milk Thistle (80% Extract)
NAC (N-Acetyl L-Cysteine)
R+ Alpha Lipoic Acid (r+ ALA)
Turmeric (95% curcuminoids Extract)
Mixed Tocotrienols (90% Delta &10% Gamma Tocotrienols)
|Homocysteine Reducing Formula:|
|Vitamin B6 (as pyridoxine HCL)||12.5 mgs||625%|
|Vitamin B12 (as methylcobalamin)||125 mcgs||21%|
|Folate (as 5-Methyl-tetrahydrofolate (5-MTHF))||200 mcgs||50%|
|Vitamin B5 (Pantothenic Acid)||100 mcgs||1%|
Below you'll find detailed descriptions about the ingredients utilized in CholesLo™ - exactly HOW it works & WHY it's better than other products. To get started, simply click on the ingredients below and a detailed description will appear under it.
Coenzyme Q-10, also known as CoQ10 and Ubiquinone, is a naturally occurring enzyme that is found in every cell in the body. Without CoQ10 NO cell in the body remains alive. The ramifications of interfering with the production of CoQ10 is insurmountable.
CoQ10’s most critical role is to protect and create energy within the cells of the heart and skeletal muscles. The heart has the greatest requirement and highest concentrations of CoQ10 than any other tissue in the body. Reduced levels of CoQ10 could be dangerous to the heart and many times a potential factor in heart disease (and prevention).
Many studies have shown that CoQIO is necessary for a healthy heart. In face, every muscle in the body needs CoQ10 to produce energy, and the heart muscle, having the greatest energy requirement, has the greatest concentration of this nutrient. Important new data shows CoQ10 improves survival in heart failure patients 1.
However, our natural production of CoQ10 peaks in our 20s and declines thereafter. With the main food sources of CoQ10 being organ meats, not usually a part of today's diets, we are prone to a deficiency, especially from middle age onward.
Many don't know, but taking cholesterol reduction statin drugs, deplete CoQ10 levels TREMENDOUSLY! The FDA has stated the following, "The clinical use of HMG CoA-reductase inhibitors (statins) and the associated depletion of the essential co-factor coenzyme Q10; a review of pertinent human and animal data." 2 The irony (once again) is that even though these drugs are created to *supposedly* help heart disease - they actually MAKE IT WORSE! This one main reason people complain about "muscle pain" - the deplesion of CoQ10 due to the statin drugs.
With CholesLo™, you don't have to worry about the statin side-effects - that's one major bonus. Additionally, with the added Co-Q10 in CholesLo's formula, your heart muscle will be receiving this valuable ingredient at the correct dosage for a stronger heart muscle.
Policosanol is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit.
Policosanol has been shown to help normalize cholesterol without any major or serious side effects such as liver dysfunction and muscle atrophy which are reported with other drugs (Mas et al. 1999). Policosanol helps to lower harmful LDL-cholesterol and helps to raise protective HDL-cholesterol, while there was no change or improvement in other treatment groups. 5
Another benefit with Policosanol is that it's very safe to use, even in children as well as the elderly. "The combination of red yeast rice extract and policosanols is both safe and effective in the treatment of hypercholesterolomic children." 3 ... And in another study "the authors have demonstrated that combined nutraceuticals (garlic, red yeast rice, policosanol) significantly reduce cholesterolemia and achieved acceptable plasma LDL-C levels in elderly hypercholesterolemic patients." 4
In both the above clinical studies, the same combinations of "effective and safe" ingredients were used, as found in CholesLo™
A study published in the Journal Nutrition Research (1987, 7:139-49) showed that a garlic extract caused a 12 to 31% reduction in cholesterol levels in the majority of test subjects after 6 months. The study showed that 73% of the subjects given the garlic (with a specific extract 1.3% alliin) experienced a greater than 10% reduction in cholesterol, compared with only 17% of the subjects in the placebo group showing the same improvement. And in another study, "garlic extract (AGE) supplementation was effective in lowering plasma concentration of total cholesterol by 7% and LDL cholesterol by 10% in hypercholesterolemic men compared with subjects consuming a placebo." 7
If you have high LDL cholesterol levels, garlic supplementation is especially important because LDL cholesterol oxidation causes atherosclerosis, and garlic specifically inhibits LDL oxidation. And garlic helps protect the arterial lining against oxidation. 6 Most importantly, garlic prevents abnormal platelet aggregation (thrombosis) via several different mechanisms. The formation of arterial blood clots is the primary cause of most heart attacks and strokes.
The heart-healthy benefits of garlic include protecting the endothelial lining of the arterial system against oxidative damage. A study published in Atherosclerosis (1999, 144:237-49) shows an actual reduction in buildup of fatty plaque in arteries in garlic-supplement users. Fatty plaque is comprised of many substances, including cholesterol. When plaque accumulates in the coronary arteries, the condition can lead to heart attack. In a study of 280 adults, German researchers reported that participants who took 900 mg of garlic powder a day had up to 18% less plaque in their arteries than those who took a placebo, or "dummy," powder.
Male study participants who took a placebo had a 5.5% increase in plaque volume, while those who took the garlic powder experienced just a 1.1% increase in plaque buildup during the 4-year study period. By comparison, women who took the garlic showed a 4.6% decrease in plaque volume, while those who took the placebo powder had a 5.3% increase. Garlic may affect plaque buildup by reducing blood platelet stickiness (aggregation) and specifically preventing the oxidation of LDL cholesterol onto the lining of the arteries. Platelet aggregation helps plaque cling to the arteries. 8
An April 1998 study reported on the effect of garlic on blood lipids, blood sugar fibrogen, and fibrinogenic activity of 30 patients who received 4 grams of garlic daily for 3 months. The patients were monitored at 1.5 and 3 months when it was determined that garlic had "significantly reduced total serum cholesterol and triglycerides, and significantly increased HDL cholesterol." With regard to fibrinogenic activity, it was determined that the garlic inhibited platelet aggregation (Prostagland. Leuk. Essent. Fatty Acids, April 1998, 58:257-63).
An earlier study in June 1994, the University of Massachusetts Medical School published a report that found that those U.S. adults who consumed one-half to one clove of garlic each day showed cholesterol levels that were reduced by 9% (JAMA, June 1, 1994, 271:1660-61). A survey of 7 out of 8 studies on garlic showed that dosages of between 600 to 900 mg of garlic powder (Allium sativum L.) produced a 5 to 20% reduction in cholesterol and triglycerides. (Fortschr. Med. (Germany) 1990, 108:49-54). Other studies have shown that much higher doses of garlic were required for cholesterol reduction.
Human patients fed a daily dose of garlic (Extract 1.3% alliin) over a 10-month study showed that "adhesion to fibrinogen was reduced by 30%-compared to placebo . . . and that . . . the beneficial effect of garlic preparations on lipids and blood pressure extends also to platelet function" (Journal of Cardiovascular Pharmacology [United States], 1998, 31:904-8). 9
This powerful ancient remedy has been re-discovered by Western culture. Gugulipid is made from the resin of the commiphora mukul tree of north central India. Gugulipid (gugulesterones) has been used for thousands of years to alleviate problems associated with obesity, acne, viral infections, and other ailments. When the correct dosage and extract is utilized (as it is in CholesLo™) a "significant reduction was observed in the values of total serum lipid and total serum cholesterol." 10
In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed an 11% decrease in total serum cholesterol, a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within 3 to 4 weeks. Patients with elevated cholesterol levels showed much greater improvement than normal patients.
The study quoted a second trial (included in the article noted above) where 205 patients receiving gugulipid at a dose rate of 25 mg at 10% extract E and Z forms 11, administered 3 times daily showed a 70% to 80% reduction of serum cholesterol, whereas no response was found in the placebo group (Journal of Associated Physicians-India, 1989, 37:328).
A placebo-controlled trial of 40 patients with high blood-fat levels showed a serum cholesterol reduction of 21.75%, with triglycerides being reduced by 27.1% in only 3 weeks, and after continuing the study for 16 weeks it was learned that HDL cholesterol was increased by 35.8% (Journal of Associated Physicians-India, 1989, 37:328).
Pantethine, a special form of vitamin B5 (pantothenic acid), has been shown to significantly lower serum cholesterol levels and increase HDL. BUT, the more common pantothenic acid has not been reported to have this effect and does NOTHING for cholestorol or triglyceride levels. 13
Three small double-blind, placebo-controlled studies suggest that pantethine can reduce total blood triglycerides and perhaps improve cholesterol levels as well10a-12a. For example, a double-blind placebo-controlled study followed 29 people with high cholesterol and triglycerides for 8 weeks 13a. The dosage used was 300 mg 3 times daily, for a total daily dose of 900 mg. In this study, subjects taking pantethine experienced a 30% reduction in blood triglycerides, a 13.5% reduction in LDL ("bad") cholesterol, and a 10% rise in HDL ("good") cholesterol. 12
The discovery that artichoke leaf extract reduces elevated cholesterol levels14 opens up exciting perspectives in the prevention and treatment of arteriosclerosis and coronary heart disease.
It was as early as the 1930s that scientists first discovered that artichoke extract had a favorable effect on atherosclerotic plaques in the arteries (Tixier, 1939). Later animal studies, in which rats were fed a high-fat diet, also showed that artichoke extract prevented a rise in serum cholesterol levels and the manifestation of atherosclerotic plaque (Samochowiec, 1959 and 1962).
In addition to findings in animal experiments (Samochowiec et al., 1971; Frohlich and Ziegler, 1973; Wojcicki 1976; Lietti 1977 and 1978), a study by Fintelmann in 1996 of 553 outpatients demonstrated a significant effect of the extract on fat (lipid) metabolism. The researchers found a significant decline in both the cholesterol and triglyceride levels in the blood, which confirmed a discovery made as early as the 1930s.
In another double-blind, placebo-controlled study of 143 people with high cholesterol, artichoke leaf extract using 5% Cynarin significantly improved cholesterol readings9. Total cholesterol fell by 18.5% as compared to 2.6% in the placebo group; LDL cholesterol by 23% vs. 6%; and LDL-to-HDL ratios by 20% vs. 7%. "In conclusion, artichoke dietary supplementation seems to positively modulate endothelial (endothelium is the inner lining of blood vessels) function in hypercholesterolemia." 15
This is a fantastic and very powerful ingredient - ONLY when used in the correct form and quantity - so please read on.
The red yeast (Monascus Purpureus) fermented on rice has been used in China for its health-promoting effects for over 2000 years. This yeast is the source of a group of compounds known as monacolins that can lower cholesterol levels by blocking a key enzyme in the liver. 16
Red yeast rice is rice that has been fermented by the red yeast, Monascus purpureus. It has been used by the Chinese for many centuries as a food preservative, food colorant (it is responsible for the red color of Peking duck), spice, and an ingredient in rice wine. Red yeast rice continues to be a dietary staple in China, Japan, and Asian communities in the United States, with an estimated average consumption of 14 to 55 grams of red yeast rice per day per person.
Red yeast rice also has been used in China for over 1,000 years for medicinal purposes. Red yeast rice was described in an ancient Chinese list of drugs as useful for improving blood circulation and for alleviating indigestion and diarrhea.
Recently, red yeast rice has been developed by Chinese and American scientists as a product to lower blood lipids, including cholesterol and triglycerides. Studies using pharmaceutical-grade red rice yeast have continued to demonstrate efficacy and safety.
Some 17 studies involving approximately 900 Chinese subjects with modestly elevated cholesterol levels have been published. In eight of these studies, there was a control group that received a placebo (a pill with no active ingredients) for comparison purposes. In nine of the studies, there was no placebo control group. 17
These studies consistently showed that :
Scientists at the UCLA Center for Human Nutrition studied a 12-week, double blind, placebo-controlled trial involving 83 American adults with borderline-high to moderately elevated cholesterol. They found that red yeast rice reduced total cholesterol, LDL cholesterol, and triglyceride levels. This study was published in the American Journal of Clinical Nutrition (1999; 69:231-7).
Lowering LDL and increasing HDL cholesterol prevents atherosclerosis (a build-up of plaque) of the heart's arteries. Since atherosclerosis causes heart attacks, lowering the LDL and increasing HDL cholesterol should lower the risk of heart attacks. In fact, several large, long-term, placebo-controlled clinical trials have shown clearly that lowering LDL cholesterol reduces the risk of heart attacks. 18
Animal studies are underway at UCLA comparing red yeast rice to a statin drug (such as Mevacor) for the prevention and treatment of atherosclerosis.
Animal studies have been conducted in China using high doses of red yeast rice products. No damage to the kidneys, liver, or other organs were demonstrated in these studies.17
Human trials in China and in the United States reported only rare and minor side effects of heartburn or indigestion with the use red yeast rice products. No liver, kidney, or muscle toxicity has been reported.
Scientists conducting the studies generally believe that red yeast rice is safe in the long-term since it has been a food staple for thousands of years in Asian countries without reports of toxicity. They attribute the safety of red yeast rice products to the process of preparation that does not involve the isolation and concentration of a single ingredient.
Plant sterols and plant stanols are collectively known as phytosterols. Plant sterols are plant compounds with chemical structures similar to that of cholesterol. Especially high sterol levels are found in rice bran, wheat germ, corn oils, and soybeans.
Interestingly, phytosterols so closely resemble cholesterol that they can actually block food-based cholesterol from being absorbed into the bloodstream. 19 The result is that both phytosterols and dietary cholesterol end up excreted in waste matter.
Because of their ability to block dietary cholesterol absorption, phytosterols can help lower your cholesterol levels. In the last few years, clinical research has also discovered other effects, including reducing symptoms of an enlarged prostate, improving the control of blood sugar among people with diabetes, and reducing inflammation among patients with autoimmune diseases such as rheumatoid arthritis and lupus.
Studies have shown that daily phytosterols can lower these cholesterol measurements by an average of 10% to 14%. 20 Because of these strong findings, the National Cholesterol Education Panel issued a new recommendation in 2001 that plant stanols and sterols be added to cholesterol-lowering regimens, along with the more traditional cholesterol-fighting tools, such as regular exercise, weight loss, and a low-fat diet.
Most of the body's supply of cholesterol (approximately 80%) is made in the liver. This process is rigorously controlled by biochemical feedback mechanisms. The amount of cholesterol produced by the liver is controlled by the enzyme HMG-CoA reductase 16 (by the way, the above ingredient Red Rice Yeast extract works mainly by inhibiting this enzyme).
As you can see, the liver is the "power house" in the body for many functions, but especially cholesterol. Many people have unhealthy livers to do lack of hydration because they don't drink enough water, to use of too many prescription drugs (or any drug for that matter), alcohol consumption and a poor diet.
So, if your liver is weak and tired from always trying to clean out and filter all the junk you are putting in your body every day, it won't have enough energy to regulate your cholesterol levels and therefore, cholesterol rises.
We've added THREE very potent liver detoxers, to help strengthen your liver and boost your immune system - Milk Thistle (80% Extract) 21, NAC (N-Acetyl L-Cysteine) 22, Alpha Lipoic Acid (ALA) 23 and Turmeric (95% curcuminoids Extract) 24. All help to lower cholesterol and triglycerides, but through an "indirect" route and work SYNERGISTICALLY with the rest of the ingredients found in CholesLo™.
But turmeric has additional benefits to liver cleansing in that it also lowers cholesterol DIRECTLY on its own.
Animals fed small doses of Turmeric (95% curcuminoids Extract) had their cholesterol levels drop by one half (50%) over those that did not receive Turmeric. It reduces cholesterol by interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids, and increasing the excretion of bile acids, according to the International Journal of Vitamin Nutritional Research (1991, 61:364-69).
The 1992 Indian Journal of Physiology reported that ten human volunteers taking Turmeric showed a 29% increase in beneficial HDL cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33%.
In January of 1997, the Journal of Molecular Cell Biochemistry reported curcumin has demonstrated, in vivo, the ability to decrease total cholesterol and LDL cholesterol levels in serum and to increase the beneficial HDL cholesterol. "Blood cholesterol was lowered significantly by dietary curcumin in these diabetic animals. Significant decrease in blood triglyceride and phospholipids was also brought about by dietary Turmeric in diabetic rats."
The research has continued and curcumin's ability to lower blood cholesterol levels was reported in the April 1998 issue of Molecular Cell Biochemistry, and again, later that year, researchers in Biofactors (1998, 8:1-2, 51-57) reported that "Turmeric extract may be protective in preventing lipoperoxidation of subcellular membranes."
Turmeric also provides an additional benefit by potentially reducing the risk of cardiovascular-related disease as it inhibits platelet aggregation and significantly decreases the level of lipid (LDL) peroxidation. "Observation of Turmeric's mechanism of action shows that it blocks the formation of thromboxane A2, a promoter of platelet aggregation, thereby inhibiting abnormal blood clot formation. Turmeric also increases a prostacyclin, a natural inhibitor of platelet aggregation" (Arzneim. Forsch., 1986, 36:715-17)."
Researchers now believe that testing homocysteine levels is over 47% more accurate at predicting heart disease, than checking cholesterol 25. So, just because you lower your cholesterol (diet, drugs, etc.), does NOT mean you're "safe" when it comes to heart disease, stokes or heart attacks.
Make sure you ALSO check your Homocysteine levels and keep them fairly low, in the range of 5-15 micromoles per liter of blood (best if it's less than 10).
About 50% of American adults have elevated blood cholesterol levels, a key risk factor for heart disease according to the National Heart, Lung, and Blood Institute. But are you aware that half of all heart attacks happen to people with normal blood cholesterol levels?
That's because your blood cholesterol provides your total cholesterol, including high-density lipoproteins (HDL) and low-density lipoproteins (LDL) but not some other important numbers, like your homocysteine level and C reactive protein.
Homocysteine, an amino acid in the blood, is associated with an increased risk of heart attack and stroke. 27 Some medical experts predict that homocysteine levels will prove to be as important as cholesterol in predicting heart health. In fact, they expect measuring homocysteine levels will become a part of regular cardiac risk assessments.
Studies have shown that high levels of homocysteine are caused by a lack of nutrients in the diet, particularly the B group of vitamins. Without these essential vitamins your body is unable to produce the enzymes necessary to remove homocysteine efficiently from your blood.
Homocysteine will cause damage to your arteries when present in high concentrations - hence the link between homocysteine and heart disease.
A lack of B Vitamins leads to elevated homocysteine levels, which is why high homocysteine and vegetarian diets are directly related. 26 Fortunately the situation is easily treatable.
In the late 60's Dr. Kilmer McCully determined through extensive research that taking adequate amounts of folic acid (vitamin B9), along with vitamins B6 and B12 your levels of homocysteine will normalize.
Numerous studies since have proven Dr. McCully's work to be 100% accurate and the correct total daily dosage for these B vitamins should be around:
Again, these are TOTAL daily dosages and this is the EXACT ratio we've used in CholesLo™. With the minimum of 2 pills daily, to a maximum of 6 pills - you will fall in the EXACT proven range to effectively reduce Homocysteine Levels!